Valeria Medina, a neuropsychologist at NeuronUP, analyzes the presence of NeuronUP in an article published in the electronic scientific journal Paradigma, No. 5 of 2026, Part 4, published in Varna, Bulgaria, as part of a review of cognitive rehabilitation technologies for multiple sclerosis.
Cognitive rehabilitation in multiple sclerosis is moving toward personalized, multidisciplinary models supported by digital tools. Based on a recent international review published in the journal Paradigma, we analyze the role of computerized cognitive training in clinical practice. In this evidence-supported context, NeuronUP is positioned as one of the technology platforms used globally to stimulate key domains such as attention, memory, processing speed, and executive functions.
Current context of cognitive rehabilitation in multiple sclerosis
Cognitive rehabilitation in multiple sclerosis is experiencing a period of transformation, driven by more personalized, multidisciplinary models supported by digital tools.
The article published in Paradigma addresses technologies for cognitive rehabilitation in multiple sclerosis and presents different strategies used in treatment, such as neuropsychological remediation, telerehabilitation, virtual reality, and other technological resources.
Within this overview, NeuronUP appears as one of the digital platforms used to work on functions such as memory and attention in patients with multiple sclerosis, alongside other software programs and neuropsychological training approaches.
This presence is relevant because it places NeuronUP within an international scientific discussion about the role of technology in cognitive rehabilitation.
Current evidence supports the potential of cognitive rehabilitation and computerized cognitive training in multiple sclerosis, especially in domains such as attention, processing speed, executive functions, and memory.
Transformation and new models of rehabilitation in multiple sclerosis
We are experiencing a particularly interesting time for cognitive rehabilitation. For years, multiple sclerosis was associated primarily with physical symptoms, fatigue, motor impairments, or mobility difficulties. However, the impact that cognitive impairments can have on the daily lives of people with this disease is increasingly recognized. Processes such as attention, memory, processing speed, or executive functions can affect daily organization, work performance, communication, and patient independence. (Chen, Chiaravalloti y DeLuca, 2021)
This shift in perspective is reflected in the review published in Paradigma, where rehabilitation for multiple sclerosis is presented as a broad, multidisciplinary process. The text does not approach intervention through a single technique, but through the combination of different therapeutic resources, including kinesitherapy, occupational therapy, speech-language therapy, neuropsychological remediation, virtual reality, robotic mechanotherapy, transcranial magnetic stimulation, and telerehabilitation.
This way of understanding rehabilitation is particularly important because the needs of patients with multiple sclerosis are not homogeneous. Each person may have a different profile of physical, cognitive, emotional, and functional symptoms, so intervention must be adapted to their difficulties, goals, and daily context.
Technology emerges in this setting as a means of expanding intervention options. The goal is not to replace professional work or turn rehabilitation into an exclusively digital intervention, but to have resources that help structure treatment more effectively, adjust difficulty, provide continuity of care, and facilitate monitoring of patient performance.
Scientific evidence on cognitive stimulation in people with multiple sclerosis
The presence of digital tools in cognitive rehabilitation does not arise in isolation. Scientific evidence from recent years has indicated that cognitive rehabilitation can be a useful intervention pathway for addressing cognitive difficulties associated with multiple sclerosis. This intervention may include restorative and compensatory approaches (Chen, Chiaravalloti y DeLuca, 2021).
Along these lines, multicomponent cognitive rehabilitation programs may provide benefits beyond cognitive performance, especially when they are integrated into multidisciplinary processes and linked to the patient’s functional goals. (Hanssen et al., 2016)
This connects with the central idea of the Paradigma review: rehabilitation in multiple sclerosis requires a broad perspective capable of combining different resources and adapting to each person’s individual needs.
Digital technologies in cognitive rehabilitation
One of the article’s most interesting points is that it integrates digital tools into a broader clinical perspective. Cognitive rehabilitation is not presented as an isolated activity, but as part of a process that can combine in-person intervention, software programs, neuropsychological training, and therapeutic follow-up.
In the section devoted to neuropsychological remediation, the text notes that, to restore functions such as memory and attention, specific software programs and neuropsychological training approaches are used. This is where NeuronUP appears as one of the tools used in the field of cognitive rehabilitation for multiple sclerosis.
This point is relevant because it helps clarify NeuronUP’s role within the article. The platform is not presented as the sole subject of analysis or as the exclusive focus of the text, but as part of a set of digital resources used in cognitive intervention.
Digital cognitive stimulation for multiple sclerosis: NeuronUP’s role in this context
NeuronUP fits into this transformation because it responds to a very specific need in clinical practice: access to tools that make it possible to work on specific cognitive goals in a structured, flexible way that can be adapted to the patient’s profile.
In cognitive rehabilitation, having digital activities is not enough. What matters is that these activities can be selected according to therapeutic goals, adjusted to the appropriate difficulty level, and incorporated into a coherent clinical plan.
From this perspective, a digital platform adds value when it helps professionals personalize intervention, observe patient progress, and make performance-based decisions over time.
NeuronUP enables professionals to:
- Select ecological and evidence-based activities designed to rehabilitate specific cognitive domains commonly affected in multiple sclerosis, such as working memory, attention, and processing speed.
- Adjust cognitive load: Precisely grade the level of demand to adapt it to daily fluctuations in the patient’s status while managing key factors such as cognitive fatigue.
- Structure a coherent plan by integrating exercises into a coordinated, multidisciplinary, and comprehensive neuropsychological intervention plan.
In multiple sclerosis, this ability to adapt is particularly useful because cognitive difficulties can vary greatly from one person to another. Some patients may need work focused more on attention and processing speed, while others may require support with memory, planning, cognitive flexibility, or strategies for better organizing their day-to-day lives (Chen, Chiaravalloti y DeLuca, 2021).
For this reason, NeuronUP offers a variety of activities with engaging designs that can be adapted to each clinical profile, defined therapeutic goals, and the patient’s performance level.
Some of the activities suggested for adults include:
| Activity name | Intervention areas | What it involves |
|---|---|---|
| Find the Monument | Processing speed, Sustained attention, Working memory | Follow directions as quickly as possible until you find the target. |
| In or out | Processing speed, Sustained attention | Determine the position (outside/inside) of different shapes in relation to one another. |
| Sequence Ordering | Episodic memory | Arrange a series of visual elements that were previously memorized. |
| Deja vu | Working memory, Sustained attention | Remember the images that were presented repeatedly after a sequence of elements. |
| Card Pyramid | Flexibility, Planning, Selective attention, Alternating attention | Place the cards shown in consecutive order upward or downward. |
| Maze | Planning | Get from one point to another within a maze. |
The value of NeuronUP lies not only in being a digital tool, but also in its ability to be integrated into a professional-led intervention plan. NeuronUP does not replace clinical reasoning; instead, it enhances it by helping professionals efficiently personalize interventions, monitor the patient’s learning curve through objective data, and make clinical decisions based on actual performance over time.
Technology expands the possibilities for intervention, but clinical judgment remains the element that gives meaning to assessment, goal selection, and process monitoring.
The future of neuropsychological intervention in multiple sclerosis
The review published in Paradigma places digital technologies within a broad model of cognitive rehabilitation for multiple sclerosis. NeuronUP appears as one of the platforms used to work on functions such as memory and attention, forming part of an international landscape of tools applied to neuropsychological intervention.
This presence should not be interpreted as a direct evaluation of NeuronUP’s effectiveness in that article, but as a reference to its role within the ecosystem of digital resources used in cognitive rehabilitation.
Current evidence suggests that cognitive rehabilitation and computerized cognitive training can provide benefits in multiple sclerosis, especially when integrated into personalized programs with functional goals and professional follow-up.
The future of cognitive rehabilitation is not simply about adding more technology, but about using it better. This means selecting tools with clinical purpose, adapting them to each patient, and always keeping the focus on what truly matters: improving daily functioning, independence, and the quality of life of people with multiple sclerosis.
References
- Chen, M. H., Chiaravalloti, N. D., & DeLuca, J. (2021). Neurological update: Cognitive rehabilitation in multiple sclerosis. Journal of Neurology, 268, 4908–4914. https://doi.org/10.1007/s00415-021-10618-2
- Hanssen, K. T., Beiske, A. G., Landrø, N. I., Hofoss, D., & Hessen, E. (2016). Cognitive rehabilitation in multiple sclerosis: A randomized controlled trial. Acta Neurologica Scandinavica, 133(1), 30–40. https://doi.org/10.1111/ane.12420
- Komissarova, N. V., Urban, M. A., Potorochina, V. D., & Lekomtseva, M. A. (2026). Когнитивные реабилитационные технологии при рассеянном склерозе [Cognitive rehabilitation technologies in multiple sclerosis]. Парадигма [Paradigma], 5(4), 254–270. https://www.paradigma.science
Frequently asked questions about cognitive rehabilitation in multiple sclerosis
1. What are the goals of cognitive rehabilitation in multiple sclerosis?
The main goal is to address cognitive impairments that affect the daily lives of people with this disease, with the aim of improving everyday functioning, work performance, and patient independence. This intervention is not isolated; rather, it forms part of a broad, multidisciplinary process adapted to individual needs and using restorative and compensatory approaches.
2. Which cognitive functions are most affected in people with multiple sclerosis?
Clinical evidence indicates that cognitive impairments in multiple sclerosis are not homogeneous, but they often predominantly affect domains such as processing speed, attention (sustained, selective, and alternating), memory (episodic and working), and executive functions, including planning and cognitive flexibility.
3. Which digital neurorehabilitation tools are currently used in clinical centers?
Today, clinical centers and neuropsychology professionals combine in-person intervention with technological resources such as telerehabilitation, virtual reality, and software for neuropsychological remediation. Cognitive stimulation software such as NeuronUP is used globally to work on specific functions, such as memory and attention, in a structured way, allowing specialists to adjust cognitive load and monitor patient progress.
4. Is computerized cognitive training effective for multiple sclerosis?
Yes, current scientific evidence supports the potential of computerized cognitive training in multiple sclerosis. Recent international studies and reviews show that these digital programs provide the greatest benefits when they are not used in isolation, but integrated into multicomponent rehabilitation programs, guided by a clinical professional’s judgment, and closely linked to the patient’s functional goals.
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